Butylated Hydroxyanisole vs Propyl Gallate: which is worse?
Quick answer: Propyl Gallate carries the heavier risk profile. Butylated Hydroxyanisole is — in the EU and — in the US; Propyl Gallate is — in the EU and — in the US.
| Property | Butylated Hydroxyanisole | Propyl Gallate |
|---|---|---|
| EU status | — | — |
| US status | — | — |
| Risk level | — | — |
| Banned in | Japan (banned for foods containing fats and oils) | Japan (banned for food use) |
| Restricted in | European Union (restricted; banned in baby food), United Kingdom | European Union (restricted to 200 mg/kg in specific fat/oil applications), United Kingdom, Australia |
| Category | additive | additive |
| Where it hides | — | — |
What is Butylated Hydroxyanisole?
Butylated hydroxyanisole (BHA) is a synthetic phenolic antioxidant preservative derived from petroleum (see also bha entry). It is a mixture of 2-BHA and 3-BHA isomers, used to prevent oxidative rancidity in fats, oils, and fat-containing foods. Chemical formula C11H16O2.
What is Propyl Gallate?
Propyl gallate is a synthetic antioxidant preservative derived from gallic acid and propanol. It prevents oxidation of fats and oils, extending shelf life of fat-containing foods. It is often used in combination with BHA and BHT for synergistic antioxidant effect. Chemical formula: C10H12O5.
Documented risks
Butylated Hydroxyanisole: IARC classifies BHA as Group 2B (possible human carcinogen) based on forestomach tumor studies in rodents at high doses. The NTP lists it as 'reasonably anticipated to be a human carcinogen.' EFSA's 2012 review found endocrine-disrupting potential. Japan banned it for food use. The FDA permits it at 0.02% of fat content. Concerns about estrogen-receptor interaction have been documented in animal studies. Contact dermatitis from cosmetic use is reported.
Propyl Gallate: Animal studies have shown propyl gallate may cause liver damage at high doses. Concerns about estrogenic activity have been raised — some studies suggest propyl gallate may weakly mimic estrogen. Contact dermatitis and allergic reactions are documented in both food and cosmetic applications. Japan banned propyl gallate for food use as part of its precautionary approach to synthetic food preservatives. NTP bioassays found dose-dependent liver effects. EFSA's re-evaluation set an ADI of 0.1 mg/kg body weight — one of the lowest ADIs for food additives, reflecting toxicological concern.
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