Calcium Propionate vs Xanthan Gum: which is worse?

What is Calcium Propionate?

Calcium propionate is the calcium salt of propionic acid, a short-chain fatty acid naturally produced during fermentation. It is one of the most widely used mold inhibitors in commercial bread and baked goods. It works by penetrating fungal cells and lowering internal pH to inhibit growth.

What is Xanthan Gum?

Xanthan gum is a polysaccharide produced by fermentation of sugars by the bacterium Xanthomonas campestris. It is a white to off-white powder that dissolves in cold or hot water to form a viscous gel. It is widely used as a thickener and stabilizer and is a key ingredient in gluten-free baking.

Documented risks

Calcium Propionate: Generally recognized as safe. However, a 2012 study in the Journal of Pediatric Child Health (Dengate & Ruben) and a 2019 study published in Science Translational Medicine found that calcium propionate induced insulin resistance in a mouse model and raised metabolic concerns. The 2019 animal study, conducted by Bhatt et al., found that propionate triggered glucagon and norepinephrine secretion. Some open-label human studies and parental reports have linked calcium propionate to irritability, sleep disturbance, and behavioral changes in sensitive children, though these lack robust clinical trial evidence. Most regulatory agencies consider it safe at current use levels.

Xanthan Gum: Generally recognized as safe by both FDA and EFSA. At high doses, xanthan gum can have laxative effects due to its fermentable fiber content, producing gas and bloating in some individuals. A 2011 case report in the journal Pediatrics raised concerns about xanthan gum in infant formula (as 'Simply Thick') being associated with necrotizing enterocolitis; the FDA subsequently advised against its use in premature infants. For healthy adults consuming normal food amounts, it poses no significant health risk.