Neotame vs Butylated Hydroxytoluene: which is worse?
Quick answer: Butylated Hydroxytoluene carries the heavier risk profile. Neotame is — in the EU and — in the US; Butylated Hydroxytoluene is — in the EU and — in the US.
| Property | Neotame | Butylated Hydroxytoluene |
|---|---|---|
| EU status | — | — |
| US status | — | — |
| Risk level | — | — |
| Banned in | — | Japan (banned for food use) |
| Restricted in | European Union (ADI 2 mg/kg body weight), Australia, Canada | European Union (ADI-based restrictions), United Kingdom, Australia |
| Category | additive | additive |
| Where it hides | — | — |
What is Neotame?
Neotame is a synthetic dipeptide sweetener — a derivative of aspartame with a 3,3-dimethylbutyl group added to block aspartame's metabolism, preventing the release of phenylalanine. This means it is safe for people with phenylketonuria (PKU), unlike aspartame. It is approximately 7,000-13,000 times sweeter than sucrose.
What is Butylated Hydroxytoluene?
Butylated hydroxytoluene (BHT) is a synthetic phenolic antioxidant preservative derived from petroleum. A white crystalline solid with formula C15H24O, it prevents fat oxidation in processed foods, cosmetics, and industrial applications. Often used synergistically with BHA.
Documented risks
Neotame: Neotame is one of the newer synthetic sweeteners with a shorter safety track record. A 2023 study published in Frontiers in Nutrition found that neotame damaged intestinal epithelial cells in vitro and disrupted the gut microbiome in mice — including reducing beneficial bacteria and increasing bacterial invasion of intestinal cells. The study observed effects at concentrations that could be achievable through high consumption of neotame-containing products. The FDA has set an ADI of 0.3 mg/kg/day, one of the lower sweetener ADIs, reflecting a conservative safety margin. Limited long-term human safety data exist compared to aspartame, acesulfame K, or saccharin, which have been used for decades. EFSA's 2010 opinion found no safety concern at permitted levels. The Frontiers in Nutrition 2023 gut study represents new concerning findings that warrant further investigation.
Butylated Hydroxytoluene: BHT has complex, bidirectional carcinogenicity data — some NTP bioassays found liver tumors in female mice at high doses, while other studies suggested BHT might inhibit cancer initiation. IARC has not formally classified BHT due to conflicting evidence. A 2017 study linked BHT to thyroid hormone disruption in female rats. The American Academy of Pediatrics (2018) recommended reducing synthetic preservative exposure including BHT in children. Kellogg's uses vitamin E in European versions of cereals that contain BHT in US versions — a commercially meaningful substitution.
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