Caramel Color IV vs Dimethylpolysiloxane: which is worse?

What is Caramel Color IV?

Caramel Color IV (Class IV caramel, E150d) is a food coloring made by heating sugar with both ammonium and sulfite compounds. This production method creates a unique set of reactive byproducts, notably 4-methylimidazole (4-MEI), which has been linked to cancer in animal studies. It is the most widely used caramel coloring in beverages like Coca-Cola and Pepsi.

What is Dimethylpolysiloxane?

Dimethylpolysiloxane (PDMS, polydimethylsiloxane) is a silicone-based polymer used as an antifoaming agent in food and beverages. It prevents the formation of foam during food manufacturing and cooking. It is the same base material used in silicone cookware, medical devices, and contact lenses.

Documented risks

Caramel Color IV: The primary concern with Caramel Color IV is 4-methylimidazole (4-MEI), a byproduct of the ammonia-sulfite caramel production process. The National Toxicology Program (NTP) found that 4-MEI caused lung cancer in male and female mice at high doses in 2-year bioassay studies, leading to California listing 4-MEI as a known carcinogen under Proposition 65 in 2011. The Prop 65 safe harbor level is 29 micrograms 4-MEI per day (the level that would cause 1 additional cancer per 100,000 people over a 70-year lifetime). CSPI testing in 2011-2012 found Coca-Cola and Pepsi sold in California contained 4-MEI levels that, at typical consumption rates, would exceed this threshold — triggering voluntary reformulation by both companies to reduce 4-MEI in their US products. The FDA reviewed 4-MEI and concluded that typical exposure levels 'are not a safety concern.' EFSA's evaluation found the NTP findings concerning but noted the margin of safety at typical European exposure levels. The cancer mechanism in mice involves high doses that may not extrapolate to typical human cola consumption.

Dimethylpolysiloxane: Dimethylpolysiloxane is generally considered non-toxic. It is not absorbed by the gut and passes through the digestive system unchanged. The FDA permits it at up to 10 ppm in cooking oils. EFSA's evaluation found no evidence of toxicity at permitted food use levels. There are no established cancer or reproductive toxicity concerns with PDMS at food use concentrations. The compound is the same base polymer used in many safe medical applications including contact lenses and breast implants (though the medical grade is different purity). The main environmental concern is PDMS persistence in the environment, as it is not readily biodegradable. Primary consumer concern is psychological rather than toxicological: the fact that it is used in both McDonald's frying oil and Silly Putty (which also contains PDMS) generates public attention, but the chemistries are actually different grades of the same polymer family.