Ensulizole vs Octisalate: which is worse?

What is Ensulizole?

Ensulizole (INCI: Phenylbenzimidazole Sulfonic Acid) is a water-soluble UVB-absorbing chemical sunscreen active. Because it is water-based, it provides a lighter, less oily feel compared to oil-soluble UV filters.

What is Octisalate?

Octisalate (INCI: Ethylhexyl Salicylate) is an oil-soluble UVB-absorbing chemical sunscreen active. It is primarily used as a UVB filter and photostabilizer for avobenzone.

Documented risks

Ensulizole: Ensulizole is approved by the FDA at up to 4% and in the EU at up to 8%. It is water-soluble and less likely to cause sensitivity reactions than oil-soluble filters. Minimal systemic absorption is documented. No established carcinogenicity or endocrine disruption. As with other UV filters, phototoxicity and photocontact dermatitis are very rare possibilities.

Octisalate: Octisalate is FDA-approved at up to 5% and EU-permitted at up to 5%. It has a good safety record and low sensitization rate. The 2019 FDA absorption study detected systemic absorption above the 0.5 ng/mL threshold, warranting further study. This does not indicate known harm. It is a salicylate; those with aspirin sensitivity should note the structural relationship, though reactions are rare.