Isopropyl Myristate vs Lanolin: which is worse?

What is Isopropyl Myristate?

Isopropyl myristate is a synthetic ester of isopropyl alcohol and myristic acid (from nutmeg or palm kernel oil). It is a dry, silky-feeling emollient that also acts as a penetration enhancer.

What is Lanolin?

Lanolin is a waxy substance secreted by the sebaceous glands of wool-bearing animals (sheep). It is extracted from raw wool during washing and consists of complex mixtures of esters, diesters, and hydroxy esters of fatty acids and alcohols. It is highly occlusive and closely mimics human sebum.

Documented risks

Isopropyl Myristate: Isopropyl myristate is CIR-safe at cosmetic use concentrations. Like IPP, it has a notable comedogenicity rating (3–4/5) and may contribute to clogged pores in acne-prone users. Its penetration-enhancing properties mean that whatever active ingredients it accompanies are delivered more deeply into the skin — this is generally desirable but should be noted. No carcinogenic or endocrine-disrupting effects are documented.

Lanolin: Lanolin is broadly safe for cosmetic use. It is FDA-approved as a skin protectant in OTC products. The primary concern is contact allergy: approximately 1–2% of the general population and up to 5–8% of eczema patients are sensitized to lanolin alcohols (the allergen fraction). Purified lanolin and lanolin alcohols in modern formulations have lower allergenicity than historical crude grades. Lanolin is not a carcinogen, hormone disruptor, or systemic toxin. It is not vegan.