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Anthocyanins is permitted by the US FDA. Several countries restrict, warning-label, or have reviewed it for safety concerns. The US has more lenient additive rules than the EU, UK, Canada, and Japan, which is why this ingredient remains widely used here.
Anthocyanins are not only safe but are associated with numerous health benefits including antioxidant, anti-inflammatory, and cardioprotective effects, extensively documented in nutritional epidemiology literature. The color is pH-sensitive (red in acid, blue/purple in neutral/alkaline), which can be a formulation challenge but presents no health risk. No significant adverse effects have been identified at food additive use levels.
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