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Isopropyl Myristate is permitted by the US FDA. Several countries restrict, warning-label, or have reviewed it for safety concerns. The US has more lenient additive rules than the EU, UK, Canada, and Japan, which is why this ingredient remains widely used here.
Isopropyl myristate is CIR-safe at cosmetic use concentrations. Like IPP, it has a notable comedogenicity rating (3–4/5) and may contribute to clogged pores in acne-prone users. Its penetration-enhancing properties mean that whatever active ingredients it accompanies are delivered more deeply into the skin — this is generally desirable but should be noted. No carcinogenic or endocrine-disrupting effects are documented.
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See the full Isopropyl Myristate deep-dive page for regulatory citations, products that contain it, and verified clean swaps.