Caramel Color Class III vs Natural Flavors: which is worse?

What is Caramel Color Class III?

Caramel color Class III (E150c) is produced by heating carbohydrates with ammonium compounds but without sulfite compounds. The ammonia processing creates byproducts including 2-acetyl-4-tetrahydroxybutylimidazole (THI) and 4-methylimidazole (4-MEI). It is commonly used in beer and malt beverages.

What is Natural Flavors?

Under FDA regulation (21 CFR 101.22), 'natural flavors' are flavoring substances derived from plant or animal sources including spices, fruits, vegetables, herbs, meats, seafood, dairy products, fermentation products, or edible yeast. The term is intentionally broad and does not require disclosure of the specific chemicals involved — a single 'natural flavor' entry on a label can represent a complex mixture of hundreds of compounds.

Documented risks

Caramel Color Class III: The 4-MEI byproduct from ammonia-processed caramel colors was classified by IARC as a possible carcinogen (Group 2B) in 2012, based on mouse studies showing increased lung tumor incidence. California's Office of Environmental Health Hazard Assessment (OEHHA) classified 4-MEI as a carcinogen under Proposition 65 in 2011, requiring warning labels on products exceeding 29 mcg per serving. EFSA reviewed 4-MEI and in 2011 concluded there was no safety concern at expected dietary exposures, though the class B carcinogen designation remains.

Natural Flavors: The term itself presents no specific health risk, but the lack of transparency is a significant concern for consumers with allergies, dietary restrictions, or sensitivities. 'Natural flavors' may contain allergens (such as shellfish, wheat, or soy derivatives), animal-derived ingredients (problematic for vegans), or added glutamates that some people wish to avoid. The Environmental Working Group (EWG) has noted that 'natural flavors' is the fourth most common ingredient on food labels, yet consumers have no right to know what specific compounds are included.