Polysorbate 80 vs Sulfur Dioxide: which is worse?
Quick answer: Both score equally on our risk model. Polysorbate 80 is — in the EU and — in the US; Sulfur Dioxide is — in the EU and — in the US.
| Property | Polysorbate 80 | Sulfur Dioxide |
|---|---|---|
| EU status | — | — |
| US status | — | — |
| Risk level | — | — |
| Banned in | — | — |
| Restricted in | European Union (ADI 25 mg/kg body weight per day), Australia | European Union (ADI 0.7 mg/kg body weight; mandatory 'contains sulfites' labeling in wine and food), United States (banned from fresh produce 1986; mandatory labeling above 10 ppm) |
| Category | additive | additive |
| Where it hides | — | — |
What is Polysorbate 80?
Polysorbate 80 (Tween 80) is a synthetic nonionic surfactant and emulsifier derived from sorbitol and oleic acid (from vegetable oils) through ethoxylation. It is widely used in food to keep water-based and oil-based ingredients uniformly mixed. Chemical formula: polyoxyethylene (20) sorbitan monooleate.
What is Sulfur Dioxide?
Sulfur dioxide (SO2) is a colorless gas used as a food preservative and antioxidant. It is the primary active form of the sulfite family of food additives. It is generated by burning sulfur or as a byproduct of certain chemical processes. In food use, it is released from various sulfite salts (E221-E228) and directly applied to some foods.
Documented risks
Polysorbate 80: Emerging research has raised concerns about polysorbate 80's effects on the gut. A landmark 2015 study in Nature (Chassaing et al.) found that dietary polysorbate 80 and polysorbate 60 at concentrations approaching food use levels promoted colitis and metabolic syndrome in genetically susceptible mice by disrupting the intestinal mucus layer and altering gut microbiome composition. The emulsifiers thinned the protective mucus layer, allowing bacteria to come into closer contact with gut epithelial cells and triggering inflammation. This study was a seminal contribution to gut health research, though it was conducted in mice and requires confirmation in humans. A 2020 follow-up study found that dietary emulsifiers including polysorbate 80 promoted gut inflammation and altered gut microbiome in human participants with Crohn's disease. People with inflammatory bowel disease may be most vulnerable to polysorbate 80's potential gut effects.
Sulfur Dioxide: Same as sodium sulfite: sulfite-sensitive individuals (1% of population, 5% of asthmatics) can experience severe reactions. SO2 in wine has been identified as a contributor to wine-induced headache and asthmatic episodes. Occupational exposure to SO2 gas causes respiratory irritation, bronchospasm, and lung damage at higher concentrations — relevant to workers in winemaking and food processing but not typical dietary exposure levels.
Scan a barcode and we'll flag both Polysorbate 80 and Sulfur Dioxide (plus 200+ other ingredients banned overseas).
Scan free →