Regulator: European Food Safety Authority (EFSA) for food; European Chemicals Agency (ECHA) for cosmetics
The European Union operates under a precautionary principle: if there is reasonable doubt about safety, a substance is restricted or banned until proven safe. This contrasts with the United States, where the FDA requires proof of harm before revoking approval. As a result, the EU has banned or tightly restricted over 1,300 cosmetic ingredients and numerous food additives that remain freely used in American products.
Titanium dioxide (E171) is banned as a food additive under EU Regulation 2022/63 following the 2021 EFSA opinion that could not rule out genotoxicity; it is still permitted in US food. Potassium bromate and azodicarbonamide are not authorised as flour treatment agents in the EU (Regulation 1333/2008 Annex II), while both remain legal in US bread. Six synthetic colours known as the Southampton Six — including Red 40 (E129, Allura Red), Yellow 5 (E102, Tartrazine) and Yellow 6 (E110, Sunset Yellow) — are authorised but must carry the mandatory warning "may have an adverse effect on activity and attention in children" (Regulation 1333/2008 Annex V). No such warning is required in the US. Ractopamine and rBST/rBGH are not authorised for use in EU livestock, so US meat and dairy produced with them cannot be sold in EU markets.
Legal in European Union, but with usage limits or mandatory warning labels that US regulators don't require.
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